Year: 2025
Type: article
Abstract: Ocuserts represent a significant advancement in ophthalmic drug delivery, offering a controlled and sustained release of medications directly to the eye. Unlike conventional eye drops and ointments, which suffer from rapid drainage and require frequent administration, ocuserts provide prolonged drug contact time, improving bioavailability and patient compliance. These thin, flexible inserts utilize advanced formulation techniques, including solvent casting, glass substrate methods, and melt extrusion, incorporating ratecontrolling membranes and biodegradable polymers to regulate drug diffusion, osmosis, or bio-erosion. Factors influencing ocusert efficacy include polymer type, drug solubility, ocular physiology, and external environmental conditions. Rigorous evaluation parameters, such as thickness uniformity, drug content assessment, and in vitro release studies, ensure safety and therapeutic effectiveness. Clinical applications of ocuserts span various ophthalmic conditions, including glaucoma, dry eye syndrome, infections, and postsurgical inflammation. Their regulatory compliance and stability testing ensure long-term efficacy and patient safety. Future developments aim at enhancing ocusert technology through personalized medicine and environmentally sustainable solutions, making them a promising alternative in ocular therapeutics.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409830271