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Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case

Year: 2025

Type: article

Abstract: Postpartum autoimmune thyroiditis (PAT) and lymphocytic hypophysitis (LH) are rare autoimmune conditions occurring during or after pregnancy. We present a case of a 35-year-old woman who developed thyroid storm because of PAT followed by LH, resulting in panhypopituitarism. Initial presentation included hemodynamic instability, altered consciousness, and hyperthyroid symptoms. She was treated for thyroid storm and subsequently developed hypernatremia, suggestive of diabetes insipidus. MRI revealed features consistent with LH. This case highlights the complex interplay between immune dysregulation and pregnancy-related hormonal changes, leading to concurrent autoimmune thyroiditis and hypophysitis. Prompt recognition and multidisciplinary management involving endocrinology, obstetrics, and critical care are essential for optimizing outcomes in such cases. Further research is needed to elucidate the underlying mechanisms and refine management strategies for these rare but potentially serious endocrine complications in the postpartum period.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.9629

Authors: Chalothorn Wannaphut, Sakditad Saowapa, Vitchapong Prasitsumrit, Kamonkiat Wirunsawanya