IL-4 exerts beneficial anti-tumor effect dependent on a short-range manner
Year: 2025
Type: article
Abstract: • IL-4 must be very close to the target cells in terms of spatial location. • Peri-tumor injection of Fc–IL-4 produces beneficial anti-tumor effects. • Blocking the lymphocyte source did not affect the enrichment of effective CD8 T cells within the TME. • The conditional knockdown of IL-4 abolished the hypoxia and cancer cell death phenotype. • 4 T-Trap caused reorganization of tumor vasculature and cancer cell death in dependent on IL-4.
Source: Cytokine
Authors: J.D. Zhang, X.Y. Xue, Y.F. Zhang, Y.F. Zhang, S.Q. Lin, Z.J. Sun, L.X. Yan, Y.G. Zhang, Y.G. Zhang, W. Wang
Institutions: Shanxi Medical University, Capital Medical University, Chinese PLA General Hospital, Shanxi Academy of Medical Sciences, Beihang University, Beijing Chao-Yang Hospital, Capital Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, China-Japan Friendship Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,220
OpenAlex ID: W4409831154