Year: 2025
Type: article
Abstract: The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is an essential cell signaling system that plays a significant role in the production of blood cells and regulates the growth, differentiation, and function of immune cells. Numerous hematological disorders can result from mutations that target this system, which can cause an excess of these cell types. This commentary perspectives JAKs in leukemia and also in chronic myeloid leukemia. This commentary also covers the relevant mutations and drug-targets for JAKs as well as the current therapeutic strategies for preventing constitutive, cytokine-independent pathway activation.
Source: Global Journal of Basic Science
DOI: 10.63454/jbs20000017
Author: Ibraheem Ashankyty
Institution: King Abdulaziz University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: King Abdulaziz University
Award: G937017603
OpenAlex ID: W4409831504