Work

Biochemical implementation of acceleration sensing and PIDA control

Year: 2025

Type: article

Abstract: Designing dependable, self-regulated biochemical systems has long posed a challenge in the field of Synthetic Biology. Here, we propose a realization of a Proportional-Integral-Derivative-Acceleration (PIDA) control scheme as a Chemical Reaction Network (CRN) governed by mass action kinetics. A constituent element of this architecture is a speed and acceleration biosensing mechanism we introduce and, subsequently, place within a feedback configuration. Our control scheme provides enhanced dynamic performance and robust steady-state tracking. In addition to our theoretical analysis, this is practically highlighted in both the deterministic and stochastic settings by regulating a specific biochemical process in-silico and drawing comparisons with a simpler PID controller.

Source: npj Systems Biology and Applications

DOI: 10.1038/s41540-025-00514-0

Authors: Emmanouil Alexis, Sebastián Espinel-Ríos, Ioannis G. Kevrekidis, José L. Avalos

Institutions: Princeton University, Commonwealth Scientific and Industrial Research Organisation, Johns Hopkins University, High Meadows Environmental Institute

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,490

Funders: National Science Foundation, U.S. Department of Energy