Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction: Necrobiosis lipoidica (NL) is a rare granulomatous disease with no standardized treatment guidelines. Case Presentation: We present a case of a patient who experienced ulcerative NL of the left leg for 5 years, during which traditional treatments proved ineffective. The patient was administered oral abrocitinib at a dosage of 100 mg per day. After 2 weeks of treatment, the patient's skin lesions ceased exuding and began to show improvement. By the 10-week mark, the patient's symptoms had significantly improved, with the ulcer healing and no new lesions appearing. No adverse events were reported during the 4-month follow-up period. Conclusion: Abrocitinib may represent a rapid and safe treatment option for patients with refractory localized NL. Further studies are warranted to confirm these findings and evaluate long-term efficacy.
Source: Case Reports in Dermatology
DOI: 10.1159/000546134
Authors: Yuping Zhang, Yirong Li, Fengjiao Meng, Chen Li
Institutions: Zhongshan People's Hospital, Guangdong Medical College
Language: English
Topic: Skin Diseases and Diabetes
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,030
OpenAlex ID: W4409837804