Work

Exogenous hydrogen sulphide sensitizes carbapenemase-producing Acinetobacter baumannii to gentamicin

Year: 2025

Type: article

Abstract: OBJECTIVE: S. METHODS: S and/or sub-inhibitory concentrations of gentamicin, azithromycin, ciprofloxacin, tetracycline, and meropenem. Bacterial growth was assessed at multiple time points to evaluate growth dynamics. RESULTS: S alone had a limited impact on bacterial growth. However, its addition reduced the minimum inhibitory concentration of gentamicin and sensitized the bacteria to sub-inhibitory concentrations of this antibiotic. CONCLUSIONS: S as an antibiotic potentiator, suggesting that the use of this combination may be a promising strategy for treating pulmonary infections caused by A. baumannii or for preventing colonization on medical devices such as catheters.

Source: Journal of Global Antimicrobial Resistance

DOI: 10.1016/j.jgar.2025.04.018

Authors: Nicolas Helsens, Jacqueline Findlay, Maxime Bouvier, Patrice Nordmann

Institutions: University of Fribourg, Université de Lille, Institut Pasteur de Lille

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,890