Acoustic Enhancer Microbubble Cavitation: A Randomized Clinical Trial Evaluating the Safety and Efficacy of a Novel Treatment for Urolithiasis
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: PURPOSE: The efficacy of ureteroscopy to treat urinary stones is often less than 60%. Acoustic Enhancer is an investigational device of microparticles with a tag designed with an affinity for calcium. We evaluated safety and efficacy of ureteroscopic laser lithotripsy with and without Acoustic Enhancer Microbubble Cavitation in a randomized clinical trial. MATERIALS AND METHODS: Patients with urolithiasis were randomized to ureteroscopic laser lithotripsy with or without Acoustic Enhancer. The end points were the proportion of patients without residual fragments ≥ 2 mm on CT 30 days post procedure (fragment-free rate) and adverse events (AEs). RESULTS: < .001). CONCLUSIONS: Although laser lithotripsy with microbubble cavitation did not increase efficacy, it was associated with significantly fewer AEs. Efficacy of microbubble cavitation may depend on laser power used. The low efficacy and high rates of AEs with ureteroscopy highlight the need for novel management approaches for urinary stones.
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4409841449