Work

Risk factors of postoperative intracranial infection in individuals suffering from hypertensive intracerebral hemorrhage

Year: 2025

Type: article

Abstract: Introduction It can be fatal for individuals with hypertensive intracerebral hemorrhage (HICH) to have a postoperative intracranial infection. It's yet unknown what risk factors led to this emergence. Therefore, the clinical variables for intracranial infection following HICH surgery were investigated. Material and methods 3253 HICH patients who underwent hematoma removal surgery were enrolled. For every patient, clinical traits were obtained. To determine the variables that were independently linked to intracranial infection following HICH surgery, univariate/multivariate logistic regression analyses were used. The analysis of the receiver operating characteristic (ROC) curve was carried out to ascertain the threshold values for continuous parameters that predict postoperative intracranial infection in HICH patients. Results 300 patients suffered from intracranial infection. Multivariate logistic regression indicated that, following HICH surgery, drainage tube retention time, duration of total parenteral nutrition (TPN) time, cerebrospinal fluid (CSF) leakage, type 1 diabetes, and plasma albumin levels were the separate susceptibility variables for cerebral infection. The ROC curve displayed that the area under the curve for drainage tube retention time (cutoff value, 7.5 days), plasma albumin levels (cutoff value, 33.75 g/L), and duration of TPN time (cutoff value, 7.5 days) were 0.756, 0.977, and 0.895, respectively. Conclusions Duration of TPN time ≥ 7.5 days, type 1 diabetes, CSF leakage, drainage tube retention time ≥ 7.5 days, and plasma albumin levels < 33.75 g/L were independent risk factors for postoperative intracranial infection in HICH patients. More attention should be provided to the contributors to minimize the frequency of this complication.

Source: Archives of Medical Science

DOI: 10.5114/aoms/202504

Authors: Heng-Yu Wang, Jun-Min Wang, Xi-Zhen Xu, Guo-Hua Mao

Institutions: Nanchang University, Second Affiliated Hospital of Nanchang University, Renmin Hospital of Wuhan University, Guangdong 999 Brain Hospital

Language: English

Topic: Intracerebral and Subarachnoid Hemorrhage Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,078