Work

The tripartite nexus among oral microbiome, DNA repair, and aging

Year: 2025

Type: article

Abstract: A compelling body of evidence highlights DNA repair as a critical regulator of biological aging and longevity. In recent years, the growing recognition of the microbiome as an essential component of our bodies has made the intersection of aging and microbiome—especially gut microbiome—one of the most prominent areas of interest in aging biology. However, the role of oral microbiome in aging and its interaction with DNA repair remains a topic that warrants thorough investigation. In this article, we will review current insights into the tripartite relationship among oral microbiome, DNA repair, and aging. Additionally, we will discuss emerging novel directions within this complex interplay that require further exploration.

Source: Oral Science and Homeostatic Medicine

DOI: 10.26599/oshm.2025.9610004

Authors: Kaiyan Wang, Jiaxi Li, Yunjia Tang, Zhiyong Mao, Yu Chen

Institutions: Tongji University, Shanghai First Maternity and Infant Hospital

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, National Institutes of Health, Fundamental Research Funds for the Central Universities, National Institute of Allergy and Infectious Diseases