Work

De Novo Design of Structure‐Tunable Multivalent Targeting Chimeras for Tumor‐Targeted PD‐L1 Degradation and Potentiated Cancer Immunotherapy

Year: 2025

Type: article

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202504233

Authors: Huiling Zhou, Bo Hou, Yiming Shan, Lujia Huang, Fangmin Chen, Siyuan Ren, Shunan Zhang, Jiaxing Pan, Yijing Dang, Haijun Yu, Zhiai Xu

Institutions: Chinese Academy of Sciences, Shanghai Institute of Materia Medica, East China Normal University, University of Chinese Academy of Sciences

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality

Awards: G1548861520, G3261735719, G7138957282

OpenAlex ID: W4409845264

FWCI: 4.177

Cites: 44

Cited by: 16

Related to: 10