Two New Diketopiperazine Alkaloids from a Deep-soil Derived Fungus Penicillium simplicissimum GZWMJZ-1612
Year: 2025
Type: article
Abstract: Two new diketopiperazine alkaloids, namely simplicamides A (1) and B (2), were isolated from the deep-soil derived fungus Penicillium simplicissimum GZWMJZ-1612. The structures of these two compounds were determined by NMR, HRESIMS, ECD calculation, and Marfey’s method. Compound 1 exhibited potent antioxidant capacity of ORAC and DPPH scavenging ability. Compound 2 displayed significant ORAC scavenging ability and α-glucosidase inhibitory activity.
Source: Records of Natural Products
Authors: Dan Wu, Wenwen He, Dongyang Wang, Liping Wang
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Chinese Academy of Sciences
Award: G3361741116
OpenAlex ID: W4409847107