Effect of oxygen on antimicrobial resistance genes from a one health perspective
Year: 2025
Type: article
Abstract: β-lactamase from the clinically relevant pOXA-48 plasmid conferred 4-fold higher ertapenem resistance in anaerobiosis. Strong changes in resistance patterns in anaerobiosis were also conserved in Klebsiella pneumoniae. Our results suggest that anaerobiosis is a relevant aspect that can affect the action and selective power of antibiotics for specific AMRs in different environments.
Institutions: Universidad Complutense de Madrid, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Centro de Investigación Biomédica en Red Enfermedades Infecciosas, Centro Nacional de Biotecnología, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,250
Funders: Comunidad de Madrid, Joint Programming Initiative on Antimicrobial Resistance, European Commission, Universidad Complutense de Madrid, Ministerio de Ciencia e Innovación, Consejería de Educación, Juventud y Deporte, Comunidad de Madrid, Consejería de Educación e Investigación, European Research Council, H2020 European Research Council, H2020 Marie Skłodowska-Curie Actions, Ministerio de Universidades
OpenAlex ID: W4409849625