Formulation and Development of Solid Nano-Emulsifying Drug Delivery System of BCS Class IV Drug Delafloxacin
Year: 2025
Type: article
Abstract: : Aqueous solubility of drugs is one of the most important factors that determine their dissolution performance and hence oral absorption and bioavailability. About 70% of new drug substances are poorly water soluble and exhibit slow dissolution rates and often incomplete oral bioavailability. The aim of present investigation is to develop a novel emulsifying drug delivery system (SNEDDS) to enhance the dissolution rate profile by increasing the solubility of Delafloxacin. The oral route is the most commonly used method for administration of drugs, with nearly 80% of the marketed dosage forms being delivered orally. This route of drug administration is the most convenient and non- invasive, leading to better patient compliance. Therefore, different formulation strategies have been investigated for enhancing the solubility of poorly soluble drugs with the aim of improving oral bioavailability. However, the optimized formulation has chosen a suitable emulsifying rate with a quick dissolution rate based on the smaller z-average diameter. The optimized Delafloxacin SNEDDS has exhibited faster dissolution rate as 97±2.07 % drug released which is clearly indicating that developed SNEDDS enhanced the dissolution rate of the drug
Author: Gokul Pandurang Mali
Institution: Dr. Babasaheb Ambedkar Technological University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409850736