Work

Mutant p53 Gain of Function: Why Many See It, Why Some Do Not

Year: 2025

Type: article

Abstract: Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients' tumors. These missense mutant proteins often exhibit pro-oncogenic activities (referred to as gain of function) in mouse models and human cell lines and correlate with poor cancer prognosis in some cases.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-24-1638

Authors: Guillermina Lozano, Carol Prives, Kanaga Sabapathy

Institutions: The University of Texas MD Anderson Cancer Center, Columbia University, Nanyang Technological University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute