Work

The role of RhoA/ROCK singaling pathway in organoid research

Year: 2025

Type: article

Abstract: Rho-associated coiled-coil containing protein kinase (ROCK) signaling is a primary regulator of cell behavior in stem cell biology and organoid systems. This review examines the diverse roles of Rho/ROCK signaling in cytoskeletal remodeling, cell adhesion, differentiation, and mechanotransduction. Special emphasis is placed on its role in organoid formation, patterning, and functional maturation. An understanding of how this pathway integrates with other signaling networks, such as Ras, Hippo, and PI3K-AKT, is crucial for optimizing organoid fidelity. We propose future research directions that enhance organoid models through targeted modulation of ROCK activity, thereby opening new opportunities for regenerative medicine and disease modeling.

Source: Organoid

DOI: 10.51335/organoid.2025.5.e4

Authors: Jung Hwa Lim, Hyun Mi Kang, Cho-Rok Jung

Institution: Korea Research Institute of Bioscience and Biotechnology

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: National Research Foundation, Korea Research Institute of Bioscience and Biotechnology, National Research Foundation of Korea, Ministry of Science and ICT, South Korea

Awards: G2134930592, G2837605527, G4362046175