Year: 2025
Type: article
Abstract: Liver fibrosis is a pathophysiological process characterized by excessive proliferation of intrahepatic connective tissue induced by chronic hepatic injury. Its molecular mechanisms include inflammation-mediated macrophage activation, hepatic stellate cell activation, and various fibrogenic pathways. Early fibrosis is reversible, which is why early diagnosis and treatment are essential.The emerging evidence underlines the importance of the transcription factor PU.1 in liver fibrosis development. This review is done to relate PU.1 with liver fibrosis for diagnosis and therapy insight into the condition.翻译搜索复制
Authors: Honglin Ju, Qian Li, Siqi Cheng, Ya Liu, Li Yang
Institution: Hunan Normal University
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409856085