Activation of transient receptor potential vanilloid 3 is required for keratinocyte differentiation and epidermal barrier formation
Year: 2025
Type: article
Abstract: changes increased with keratinocyte differentiation. The TRPV3 antagonist, ruthenium red, inhibited both keratinocyte differentiation and TRPV3 upregulation. TRPV3 agonists (2-APB/carvacrol) facilitated early differentiation but paradoxically downregulated TRPV3 expression at higher concentrations. Moderate TRPV3 activation by lower agonist concentrations enhanced skin barrier recovery, while higher concentrations hindered recovery and induced immune cell infiltration. These findings highlight the dual role of TRPV3 in skin homeostasis and suggest that targeted modulation of TRPV3 could be a promising strategy for treating skin disorders.
DOI: 10.4196/kjpp.24.324
Institutions: Seoul National University, Dongguk University
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
Awards: G166053027, G6811352858, G7103839705
OpenAlex ID: W4409858030