Initial Analysis of Several Clinical Features and Sperm Concentration in Men With Pericentric Inversion of Chromosome 9 Finding Assisted Reproductive Treatments
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: To evaluate some clinical features and sperm concentration among men with pericentric inversion of chromosome 9, and to find assisted reproductive treatments. Methods: A retrospective, descriptive study was conducted on 36 men with pericentric inversion of chromosome 9 at the Military Institute of Clinical Embryology and Histology, Vietnam Military Medical University, from January 2020 to December 2023. Age, height, weight, and body mass index (BMI) were recorded. Semen analysis was conducted according to World Health Organization (WHO) 2021 guidelines. Results: 36 male patients with pericentric inversion of chromosome 9 were observed, of which the majority had variant 46,XY,inv(9)(p11q13) with a rate of 72.22%. Evaluation of clinical characteristics showed that height, weight, and BMI were all within the normal ranges for men. Semen analysis: 24/36 patients (66.67%) had normal sperm concentration; only 12/36 patients (33.33%) were observed to have a slight decrease in sperm concentration; no cases of severe oligozoospermia or azoospermia were recorded. A case of pericentric inversion of chromosome 9 was recorded as inherited in the family after natural reproduction. Conclusion: In men who found assisted reproductive treatments in our assisted reproductive center and were recorded pericentric inversion of chromosome 9 in the karyotype, age, height, weight, and BMI were all within the normal ranges of Vietnamese people and manifested mild oligozoospermia or normal sperm concentration.
Authors: The Son Trinh, Ngoc Nhat Nguyen, Minh Phuong Nguyen, Van Sinh Dinh, Sy Hung Ho
Institution: Vietnam Military Medical University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4409858358