Work

Chacma baboon natural anticoagulants and factor VIII activities

Year: 2025

Type: article

Abstract: Non-human primates are useful models of human haemostasis, but distinctions do exist. These differences are essential to identify and quantify to better characterise the Chacma baboon's coagulation system. The Chacma baboon's factor VIII and natural anticoagulants were characterised and compared to human reference ranges. Parameters were measured using commercial chromogenic and clot-based assays, in 40 Rhesus negative, ABO typed, male and female Chacma baboon platelet poor plasma samples. Free protein S concentration, protein C, protein S and factor VIII activity reference intervals revealed important differences, while antithrombin was similar to humans. Between sexes, reference intervals largely overlapped but were wider for free protein S and protein S activity. Factor VIII activity was 14% lower in group O baboons. This research has quantified some of the coagulation similarities and differences between Chacma baboons and humans.

Source: Scientific Reports

DOI: 10.1038/s41598-025-94503-2

Authors: Quintin Andre van Staden, Sarah Meiring Muriel, Conradie Charmaine, Joubert Jaco

Institutions: National Health Laboratory Service, University of the Free State

Language: English

Topic: Blood Coagulation and Thrombosis Mechanisms

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690