Research progress on the effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on lung cancer
Year: 2025
Type: article
Abstract: Lung cancer is one of the most common malignancies with the highest morbidity and mortality in the world, and the existing treatment methods often face challenges such as toxic side effects and drug resistance. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have become a promising new strategy in cancer treatment due to their unique biological characteristics (e.g., self-renewal, multi-differentiation and immune regulation). This paper reviews the mechanism of hUC-MSCs in regulating the proliferation, apoptosis, invasion and metastasis of lung cancer cells and tumor microenvironment, and discusses the dual effect of HUC-MSCs in promoting or inhibiting cancer. In addition, this paper also discusses the engineering transformation strategy of hUC-MSCs as gene and drug carriers, which provides a new research idea and theoretical basis for the development of hUC-MSC-based targeted therapy for lung cancer.
Source: Discussion of Clinical Cases
DOI: 10.5430/dcc.v11n1p25
Authors: Yan Zhang, Xingyang Pang, Yonggang Li, Yanwei Guo
Institution: Inner Mongolia Medical University
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409862827