Work

Synthesis of Rh-MOF/PVA-PVP nanofibers for skin cancer and infection inhibition

Year: 2025

Type: article

Abstract: Using electrospinning for nanofiber production, we can create unique materials with multiple applications in various industries, including medical bandages and wound dressings. One of the most important features of these materials and using the electrospinning technique, is the incorporation of compounds and metals into their structure. In this study, a new metal-organic framework (MOF) was synthesized from rhodium, a metal with significant biological potential, which was then used to produce new nanofibers using electrospinning technique, (Rh-MOF/PVA-PVP nanofiber) by mixing polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP). The newly synthesized nanofiber was tested against common microbial skin pathogens and cancer cells, showing significant inhibition. Specifically, an IC50 value of 19.45 μg/mL against cancer cells and MIC values ranging from 4 μg/mL to 64 μg/mL μg against skin pathogenic strains were observed. This notable inhibitory ability can be attributed to both physical characteristics (with specific surface area of 2,348 m2/g), and chemical factors, including the active compounds present in its rhodium (Rh) structure. The synthesized Rh-MOF/PVA-PVP nanofiber has the potential for use in developing bioactive bandages, and wound dressings.

Source: Frontiers in Chemistry

DOI: 10.3389/fchem.2025.1575183

Authors: Ali Altharawi, Taibah Aldakhil, Manal A. Alossaimi

Institution: Prince Sattam Bin Abdulaziz University

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801