Work

Multi-regional sequential pain syndrome

Year: 2025

Type: article

Abstract: Objective: To report a novel clinical entity, "Multi-regional Sequential Pain Syndrome" (MRSPS), and evaluate the relationship between hypoperfusion, cryptogenic vertebral artery dissection (CVAD), and MRSPS. Methods: A 59-year-old female patient, with a chronic MRSPS condition spanning 10-30 years, underwent a comprehensive diagnostic evaluation including cranial CTA, MRI, DSA, and CT perfusion, culminating in the identification of CVAD via dynamic contrast-enhanced computed tomography (DCE-CT). The treatment strategy integrated repairing CVADs with stent implantation to address the hypoperfusion and MRSPS. Results: Following intervention, hypoperfusion achieved complete improvement, and the patient achieved the complete resolution of pain and vertigo, with the modified Rankin Scale (mRS) score of 0 at the 1-year follow-up, signifying full neurological recovery. Conclusion: CVADs, a key cause of brain tissue hypoperfusion in MRSPS, can be effectively treated by repair to alleviate the syndrome.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2025.1553455

Authors: Xiao Yang, Kai-Jun Zhao, Jian-Min Liu

Institutions: Tongji University, Shanghai East Hospital, Second Military Medical University, Changhai Hospital

Language: English

Topic: Cerebrovascular and Carotid Artery Diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801