Design and Combinatorial Synthesis of Biomimetic Multivariate Metal–Organic Frameworks for Efficient Drug Loading
Year: 2025
Type: article
Abstract: Multivariate metal–organic frameworks (MOFs) covering diverse iso‐reticular materials while encompassing tunable function through the spatial composition of the organic functional groups are an excellent starting point for developing sequence‐dependent materials. There remains a demand for synthesizing an extensive library of multivariate MOFs for function‐targeted selection, similar to the process of directed evolution in improving the function of proteins by selecting the best mutant from a large mutant library. The design of biomimetic multivariate MOFs (bMTV‐MOFs) is reported that incorporate the panel of functionality presented in amino acids to enable the complexity and adjustability of proteins to the structure of MOFs. A total of 1089 MOFs, ranging from single‐component to multivariate structures, are synthesized in a combinatorial manner for the delivery of the verteporfin, a photosensitive drug. Tertiary bMTV‐MOFs demonstrated superiority in the adsorption and release of verteporfin. In vitro studies on various cancer cell lines demonstrated a 23 to 68‐fold enhancement in efficacy for photodynamic therapy using the privileged A1F6H3 or A3D1H6 bMTV‐MOFs over pristine MOFs.
Source: Small
Authors: Qingqing Zuo, Xin Tang, Yintao Li, Yixian Bao, Min Chen, Pengfei Ji
Institution: Zhejiang University
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4409866565