HAVoc on Red Cells: An Unusual Case of Hypoxia Complicated by Severe Hemolysis with an Underlying Glucose-6-phosphate Dehydrogenase Deficiency in Viral Hepatitis A Infection
Year: 2025
Type: article
Study design: Case Report
Abstract: A. His initial liver function tests showed worsening coagulopathy, transaminitis, and jaundice.He was managed conservatively by the department of gastroenterology there; despite improvement in LFTs, he developed hypoxia and had increasing oxygen IntroductIonViral hepatitis is a major health problem worldwide, among which Hepatitis A virus (HAV) infection is the most prevalent hepatotropic virus and causes acute hepatitis in general.Although hemolytic anemia is a rare manifestation of viral hepatitis A, it can be very serious if the individual has glucose-6-phosphate dehydrogenase (G6PD) deficiency. 1 A G6PD genetic mutation causes G6PD deficiency, an X-linked recessive genetic condition.Hemolytic anemia occurs when red blood cells (RBCs) breakdown too soon due to the G6PD enzyme deficiency.If there is any additional damage to the RBCs in these patients, such as oxidative stress, membrane defects, or enzyme deficiencies like G6PD deficiency, hemolysis may become more severe.2 Here is a case of a 31-year-old young adult who was initially diagnosed with viral hepatitis A and worsening hypoxia, which was found to be due to acute hemolysis secondary to G6PD deficiency. case descrIptIonA 31-year-old guy arrived with a history of a 2-week high-grade fever and a 10-day period of yellowish discoloration in his eyes and urine.In addition, he experienced vomiting and dull, exhausting discomfort in the right hypochondrium and epigastric area.He was initially treated at another center and was diagnosed with hepatitis 1,
Authors: Anoop Kumar, Shon Philip, Gangaprasad G
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409870071