Work

Putting AML Differentiation States on the BoneMarrowMap

Year: 2025

Type: article

Abstract: This article presents a novel computational tool, "BoneMarrowMap," that enables the mapping of leukemic single-cell RNA sequencing datasets to hematopoietic differentiation states. By utilizing BoneMarrowMap for a large-scale single-cell RNA sequencing reanalysis, the authors discover 12 recurrent acute myeloid leukemia differentiation patterns linked to prognosis and treatment and dissect leukemic clonal architectures within individual patients. See related article by Zeng and colleagues, p. 307.

Source: Blood Cancer Discovery

DOI: 10.1158/2643-3230.bcd-25-0083

Authors: Jonas Berger, Livius Penter

Institutions: Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Deutsche Forschungsgemeinschaft, Else Kröner-Fresenius-Stiftung, Deutsche Krebshilfe, Berlin Institute of Health