Work

Targeting inflammasome pathway towards therapeutics of neurodegenerative diseases.

Year: 2025

Type: article

Abstract: Inflammasomes are intracellular protein complexes that play a crucial role in regulating the innate immune response and defending against harmful insults. Increasing evidence indicates that activation of the inflammasome pathway in brain cells plays an important pathological role in the pathogenesis of neurodegenerative diseases. Targeting the inflammasome pathway is a promising strategy for developing new treatments for neurodegenerative diseases. In this review, we have recapped the wide-ranging involvement of inflammasome pathway activation in neurodegenerative diseases and highlighted the current approaches for the development of therapeutic strategies targeting this pathway.

Source: Organelle

DOI: 10.61747/0ifp.202503001

Authors: Wanli Smith, Mali Jiang, Jazlynn Meza, Gabriela Mercado

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke