Work

Prevalence and Characteristics of Pathogenic Variants in Taiwanese Patients With Cerebral Small Vessel Disease

Year: 2025

Type: article

Abstract: Background and Objectives: The Taiwan-Associated Genetic and Non-genetic Small Vessel Disease (TAG-SVD) cohort prospectively enrolls patients with cerebral small vessel disease (SVD). The aim of this study was to determine the prevalence and characteristics of monogenic SVD in patients within the TAG-SVD cohort. Methods: . Results: pathogenic variants. Discussion: EGFr 7-34 variants, but without anterior temporal WMH involvement. These findings underscore the importance of genetic screening to understand SVD heterogeneity and guide personalized management.

Source: Neurology Genetics

DOI: 10.1212/nxg.0000000000200258