Year: 2025
Type: article
Abstract: -null cells responded to external calcium stimuli compared to wild-type cells. In the presence of W7, a calmodulin antagonist that inhibits calcium release from acidic stores, cells exhibited a marked reduction in the major calcium induction peak at 20 s post-stimulation. Our results suggest that there are at least two pathways to increase the intracellular calcium level in response to external calcium stimuli, and that intracellular acidic calcium stores partially contribute to the second major peak of calcium induction following external stimuli. It appears that G proteins, cGMP, and IplA are involved in calcium homeostasis upon external calcium stimulation, and play an important role in modulating the timing and amplitude of calcium responses.
Authors: Dahyeon Kim, Jiseong Seo, Taeck Joong Jeon
Institution: Chosun University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Award: G3014316012
OpenAlex ID: W4409875939