Work

Myokines and interorgan crosstalk: bridging exercise to health promotion and disease prevention

Year: 2025

Type: article

Abstract: Exercise is known to promote physical health and reduce the risk of various diseases. During exercise, skeletal muscle actively contracts to perform movements and secretes hormone-like molecules termed myokines. The beneficial effects of exercise have been assessed with respect to myokine production, and those of irisin on bone, adipose tissue, and the brain have been well documented. Irisin, through its interactions with the integrin αV family, plays a crucial role in bone maintenance, metabolic regulation, and cognitive function. Building on the established understanding of irisin, this discussion will examine the functions and effects of other myokines as key secretory factors in exercise, emphasizing their broader roles in health promotion and the potential for new therapeutic strategies in disease prevention and treatment.

Source: Annals of Pediatric Endocrinology & Metabolism

DOI: 10.6065/apem.2448218.109

Authors: Junseo Ha, Suchan Sung, Hyeonwoo Kim

Institution: Korea Advanced Institute of Science and Technology

Language: English

Topic: Exercise and Physiological Responses

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Research Foundation, National Research Foundation of Korea