FeniCaff: Mouth-Dissolving Caffeine Tablets Utilizing Fenugreek Mucilage as a Natural Superdisintegrant
Year: 2025
Type: article
Abstract: The demand for mouth-dissolving tablets (MDTs) has increased due to their convenience for patients with dysphagia, pediatric, and geriatric populations. This study focuses on the formulation and evaluation of mouth-dissolving caffeine tablets using fenugreek mucilage as a natural superdisintegrant Strong muscle relaxant caffeine helps control elevated muscular tone linked to spasticity. This study examined and compiled eight different formulations of mouth-dissolving tablets (FDTs) containing caffeine. These tablets were made using super disintegrants, following official guidelines and standards. A 2-level, 3-factorial design was employed to optimize the formulation parameters, investigating the effects of fenugreek mucilage concentration, caffeine dose, and compression force on tablet properties. The prepared tablets were evaluated for disintegration time, wetting time, drug release profile, and mechanical strength to determine their efficiency in rapid drug delivery. Results indicated that fenugreek mucilage significantly enhanced disintegration and dissolution rates, making it a promising natural alternative to synthetic superdisintegrants. The optimized formulation met pharmacopeial standards and demonstrated improved caffeine release, highlighting the potential of fenugreek mucilage in MDT formulations.
Authors: Manish Kushwaha, Dev Soni, Dimple Shukla, Chiranji Kumavat
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4409893530