Shh agonist enhances maturation in homotypic Lgr5-positive inner ear organoids
Year: 2025
Type: article
Abstract: This integrated approach elucidates critical pathways and cellular dynamics underpinning stereocilia maturation and functional HC development in EIOs. These findings provide new insights into the molecular regulation of HC maturation and support the utility of Shh-modulated IEOs as a promising platform for inner ear regeneration and therapeutic development for inner ear regenerative therapies.
Source: Theranostics
DOI: 10.7150/thno.107345
Institutions: Dankook University, Dankook University Hospital, Ajou University
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4409898808