Targeting endothelial MYC using siRNA or miR-218 nanoparticles sensitizes chemo- and immuno-therapies by recapitulating the Notch activation-induced tumor vessel normalization
Year: 2025
Type: article
Abstract: Together, our data have demonstrated that Notch activation normalizes tumor vessels by repressing the proliferating TEC subset via MYC, and targeting endothelial MYC using nanoparticles bearing siRNA or miRNA is an efficient strategy for tumor anti-angiogenic therapy.
Source: Theranostics
DOI: 10.7150/thno.112023
Authors: Xianchun Yan, Ziyan Yang, Xiuli Cao, Liang Liang, Yanyan Duan, Peiran Zhang, Yixuan Feng, Ting Wen, Shanqiang Luo, Lintao Jia, Jiaxing Sun, Hua Han
Institutions: Air Force Medical University, Xijing Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4409898857