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GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism

Year: 2025

Type: article

Abstract: Our study not only affirm the role of GPx4 in GC progression but also highlight it as a promising target for reshaping the immune microenvironment.

Source: Theranostics

DOI: 10.7150/thno.108817

Authors: Jingli Xu, Chunyan Weng, Yanqiang Zhang, Qianyu Zhao, Jiahui Chen, Siwei Pan, Yan Wang, Ruolan Zhang, Yuqi Wang, Weiwei Zhu, Mengxuan Cao, Dan Zu, Shengjie Zhang, Zhiyuan Xu, Can Hu, Xiangdong Cheng

Institutions: Zhejiang Chinese Medical University, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4409898942

FWCI: 6.479

Cites:

Cited by: 22

Related to: 10