SIRT3 is required for the protective function of ketogenic diet on neural inflammation and neuropathic pain
Year: 2025
Type: article
Abstract: experiments revealed KD-induced upregulation of uncoupling protein 2 (UCP2), sirtuin 3 (SIRT3) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) in the spinal dorsal horn. Importantly, SIRT3 deficiency abolished KD's protective effects against neuropathic pain and reduced BHB levels, potentially attributable to diminished expression of hepatic ketone body synthases and spinal ketone body-utilizing enzymes. These findings highlight SIRT3 as a promising therapeutic target for neuropathic pain within the ketogenic diet paradigm, providing a foundation for novel therapeutic strategies.
DOI: 10.7150/ijbs.110921
Authors: Mengqiu Deng, Yuanyuan Fang, Yan Chu, Ruifeng Ding, Xiaoyi Fan, Huawei Wei, Honghao Song, Guowei Jiang, Hailing Zhang, Chaofeng Han, Hongbin Yuan
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4409899046