Microbiota intestinale e diabete mellito di tipo 1: il mimetismo molecolare ed il ruolo della barriera intestinale
Year: 2025
Type: article
Abstract: Type 1 diabetes is an autoimmune disease resulting from the immune-mediated destruction of insulin-producing beta cells in the pancreas. Recent findings highlight microbiota as a possible contributor to the disease. Gut dysbiosis may lead to increased permeability, microbial antigen translocation and immune dysregulation, promoting pancreas autoimmunity. Mechanisms such as molecular mimicry and metabolic shifts may drive the autoimmune process. Understanding these interactions could pave the way for new therapeutic avenues targeting the microbiota to preserve beta cell mass.
Source: il Diabete
DOI: 10.30682/ildia2501a
Authors: Vittoria Palmieri, Marika Falcone
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4409903682