Work

Effect of Andrographis paniculata and Melia azadirachta against the Dengue virus

Year: 2025

Type: article

Abstract: Dengue infection is emerging as a global threat due to increased mortality and morbidity, especially in tropical and sub-tropical regions. Therefore, it is of interest to evaluate the antiviral activity of Andrographis paniculata and Melia azadirachta against Dengue virus-1 in a vero cell line using a cytopathic effects (CPE) reduction assay and cytotoxicity assessed by MTT assay. GC-MS analysis was conducted to identify phytochemicals in the plant extracts. Both extracts showed potent antiviral activity at 150 μg/ml and were non-toxic up to 1.5 mg/ml, with 100% cell viability. These findings suggest that A. paniculata and M. azadirachta are promising candidates against Dengue virus-1, warranting further investigation into their active compounds.

Source: Bioinformation

DOI: 10.6026/973206300210730

Authors: Kamalraj Mohan, KP Gautam Srinivas, Jeevan Malaiyan, Suresh Arumugam

Institutions: Meenakshi Academy of Higher Education and Research, Meenakshi Medical College Hospital and Research Institute

Language: English

Topic: Andrographolide Research and Applications

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409904018

FWCI:

Cites: 1

Cited by:

Related to: 10