Comparative Study Between Free Disease Interval of Modified Radical Mastectomy Versus Conservative Breast Surgery in Patients with Triple-Negative Breast Cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Breast cancer is a significant concern in modern research due to its mortality and associated psychological aspects. In recent years, breast conservation surgery (BCS) and modified radical mastectomy (MRM) have been widely used in the treatment of early‐stage breast cancer. This study aims to compare the free disease interval of modified radical mastectomy (MRM) versus conservative breast surgery (Lumpectomy) in patients with triple-negative breast cancer stage I and stage II. Methods: In this retrospective-based record comparative study, 100 triple negative (invasive ductal carcinoma confirmed through histopathology) breast cancer females' stage I and stage II were enrolled, the study was conducted at 6 October University Hospital. This study compares free disease interval (3-5 years) of modified radical mastectomy and conservative breast surgery. The study record was over a period from 2015 to 2022. Results: There was a significant positive correlation between age and metastatic patients (r = 0.329; P <0.010*). There was a significant positive correlation between metastatic patients and grade II, III & IV (r = 0.777, P <0.0001; r = 0.433, P <0.0001). There was a significant positive correlation between metastatic patients and stage Tmic/ T1a/ T1b, T1c, and T2 (r = 0.624; P <0.010*; r = 0.517; p <0.0001; r = 0.494, p <0.0001). There was a significant positive correlation between metastatic patients and lymph nodes N0 and N1 (r = 0.497; P <0.010*; r = 0.195, p <0.044*). Conclusion: modified radical mastectomy and conservative breast surgery in triple-negative breast cancer female patients, both techniques represent successful rates, however; conservative breast surgery had a higher successful rate than modified radical mastectomy.
Source: Journal of Neonatal Surgery
Authors: Ahmed Zaki Ghareeb, Adel Morad Abdallah, Ahmed Sobhi Mahmoud, Emad M Mostafa
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409904078