Work

Pericytes under pressure: TRPC3 channels as gatekeepers of capillary flow

Year: 2025

Type: article

Abstract: Intrinsic control of cerebral blood flow in response to intravascular pressure is traditionally attributed to smooth muscle cells in arterioles. However, in this issue of Science Signaling , Ferris et al. demonstrate that capillary constriction is caused by pressure-induced depolarization of pericytes, mural cells that encircle capillaries, and is mediated by TRPC3 cation channels, identifying the channel as critical for fine-tuning brain perfusion.

Source: Science Signaling

DOI: 10.1126/scisignal.adw7185

Author: Scott Earley

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke