Work

Synthesis of Fused Isoxazoles via Intramolecular Nitrile Oxide Cycloaddition

Year: 2025

Type: article

Abstract: We report an efficient and straightforward strategy for the synthesis of substituted dihydrofuro[3,4‐c]isoxazoles and dihydro‐4H‐pyrano[4,3‐c]isoxazoles via intramolecular nitrile oxide cycloaddition (INOC) reactions of aldoximes, employing (diacetoxyiodo)benzene (PIDA/DIB/PhI(OAc)₂) as a single, cost‐effective oxidizing agent. This method enables the practical and economical synthesis of structurally diverse and highly functionalized oxygen‐bridged isoxazole derivatives under mild reaction condition with short reaction time.

Source: ChemistrySelect

DOI: 10.1002/slct.202501315

Authors: Vikash Kumar, Ashutosh Dey, Rohit Kumar Maurya, Megha Kumari, Mahender Khatravath

Institution: Central University of South Bihar

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Science and Engineering Research Board

Award: G7866736193