Year: 2024
Type: article
Abstract: This study explores the anti-inflammatory effects and mechanisms of Sojae Semen Praeparatum (SSP) through network pharmacology and animal experimentation. First, active ingredients and therapeutic targets in SSP were identified using the TCMSP database and literature review. In addition, inflammation-related ingredients, targets, and pathways were sourced from databases such as TTD, KEGG, and Drug Bank. These findings were used to construct and analyze networks of ingredient-target-pathway interactions, target distribution across tissues, and key protein associations. Finally, a rat paw edema test was performed to experimentally confirm SSP's anti-inflammatory effects. The results identified 16 inflammation-related active ingredients in SSP, which act on 33 target proteins across 73 pathways. Furthermore, SSP extracts significantly reduced paw edema in rats, indicating strong anti-inflammatory potential. This study demonstrates that SSP exerts anti-inflammatory effects through multi-ingredient, multi-target, and multi-pathway interactions, providing a scientific basis for its clinical application.
Authors: Siqing Wen, Yuting Xu, Linghao Qin, Xiaoming Wang
Institution: Guangdong Pharmaceutical University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4409909030