Work

Management of neurotrophic corneal ulcer with a topical liposomal ozonated oil: A report on three clinical cases

Year: 2025

Type: article

Abstract: Purpose: To present three cases of neurotrophic corneal ulcer successfully treated with topical liposomal ozonated oil (Ozonest®) eye drops and to assess its potential usefulness in preventing corneal infection and promoting epithelialization. Observations: Neurotrophic corneal ulcers require appropriate therapy that includes re-epithelialization and prevention of infection usually with antibiotic therapy. The emergence of multidrug-resistant bacterial strains due to the overuse of antibiotics in the treatment of infectious diseases has prompted researchers to investigate new antimicrobial formulations. Liposomal ozonated oil has demonstrated antiseptic (antibacterial, antifungal and antiviral) and tissue repair properties, making it a promising candidate for the prevention and treatment of acute and chronic local infections. Additionally, its specific formulation ensures good tolerability and biocompatibility with the ocular surface. In the three cases of neurotrophic ulcer presented here, topical liposomal ozonated oil (Ozonest®) was used, resulting in good resolution and complete re-epithelialization without superinfection. Conclusions and importance: The use of topical liposomal ozonated oil (Ozonest®) may have an antiseptic role and help in the closure of neurotrophic ulcers.

Source: American Journal of Ophthalmology Case Reports

DOI: 10.1016/j.ajoc.2025.102344

Authors: Isabel Mogollón Giralt, Ana Boto de los Bueis, Ana Martín Ucero, Paola Vázquez Colomo

Institution: Hospital Universitario La Paz

Language: English

Topic: Medical and Biological Ozone Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,590