Work

The role of infraclavicular and supraclavicular lymph nodes in breast cancer patients receiving neoadjuvant chemotherapy: implications for regional lymph node classification

Year: 2025

Type: article

Abstract: Background: Metastasis to the infraclavicular and supraclavicular lymph nodes (ISLNs) is an important factor that predicts poor survival in patients with breast cancer; however, pathological nodal staging does not traditionally include ISLNs because of their non-routine surgical dissection. This study aimed to evaluate the prognostic impact of ISLN metastasis and propose a refined nodal staging system tailored for patients undergoing neoadjuvant chemotherapy (NAC). Methods: We retrospectively reviewed 1,072 patients with breast cancer with or without ISLN metastasis who received NAC at two institutions (Fujian cohort and Hebei cohort) from 2010 to 2022. We conducted detailed survival analysis to evaluate the diagnostic consistency and prognostic significance of ISLNs. Results: < 0.001). After adjusting for potential confounders, ISLN involvement persisted as an independent predictor of both PFS and OS. We propose a refined axillary classification that combines pathological axillary staging post-NAC with ISLN involvement, revealing 3-year PFS rates of 95.3 %, 87.6 %, 73.4 %, and 64.5 % for the respective four groups defined by this refined classification combining axillary stage and ISLN status. Conclusions: Involvement of the ISLNs was associated with a worse prognosis, underscoring their prognostic value. This finding highlights the potential of ISLN status to influence decisions regarding adjuvant treatment in patients with breast cancer.

Source: Journal of the National Cancer Center

DOI: 10.1016/j.jncc.2025.02.005