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Hemophagocytic Lymphohistiocytosis in the Setting of Progressive Chronic Lymphocytic Leukemia With Five Concurrent Life-Threatening Infections

Year: 2025

Type: article

Abstract: Untreated hemophagocytic lymphohistiocytosis (HLH) can be fatal and requires a high degree of clinical suspicion in the setting of an underlying autoimmune disorder, infection, or malignancy. In the presence of multiple infections, it can be challenging to treat the disease, given organ failure and limited options. We present a case of HLH in a patient with chronic lymphocytic leukemia, who was found to have multiple bacterial and fungal infections simultaneously, due in part to construction work on his 200-year-old home.

Source: Cureus

DOI: 10.7759/cureus.83209

Authors: Heenaben Patel, John Patresan, Victoria Krzywicki, Andres Ramirez Gamero, Gerald Colvin

Institution: Roger Williams Medical Center

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409913348