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Double Trouble: A Case Report of Hydralazine-Induced Vasculitis and Lupus

Year: 2025

Type: article

Abstract: We present a rare case of hydralazine-induced antineutrophil cytoplasmic antibody (ANCA) vasculitis and lupus, characterized by the simultaneous and severe involvement of multiple organ systems. Following outpatient hydralazine dose escalation, a 77-year-old woman developed hypoxic respiratory failure secondary to diffuse alveolar hemorrhage, acute kidney injury with crescentic glomerulonephritis, and pancytopenia. Serologic testing revealed positive antinuclear antibody (ANA), dsDNA, anti-histone antibody, and P-ANCA, supporting the diagnosis of drug-induced autoimmune syndrome. This case highlights the risk for severe multi-organ dysfunction in drug-induced lupus and vasculitis, emphasizing the need for vigilance in recognizing such complications.

Source: Cureus

DOI: 10.7759/cureus.83202

Authors: Malika Ibrahim, Thanda Aung, Sravani Penumarty

Institution: University of California, Los Angeles

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409915455