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Base‐Promoted Solvent‐Tuned Annulation: A Route to Sulfonylated Isochromenes from Sulfonyl Enynals

Year: 2025

Type: article

Abstract: A base‐promoted annulation via 1,2‐addition/alkyne‐allene isomerization/oxa‐Michael cyclization of sulfonyl enynals for the synthesis of sulfonylated isochromene is developed. The choice of solvent plays a crucial role in this transformation to give the sulfonylated iscohromenes. The reaction mechanism is supported by the react‐IR experiment. To emphasize the practical utility, the sulfonylated isochromene is deftly elaborated into diversely substituted naphthalene and isocoumarine.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500297

Authors: Santosh J. Gharpure, Shipra Somani, Dipak J. Fartade, Santosh K. Nanda

Institution: Indian Institute of Technology Bombay

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Indian Institute of Technology Bombay, Science and Engineering Research Board

OpenAlex ID: W4409921438

FWCI: 0.596

Cites: 34

Cited by: 2

Related to: 10