Work

Integrating Equation Coding with Residual Networks for Efficient ODE Approximation in Biological Research

Year: 2025

Type: article

Abstract: Biological research traditionally relies on experimental methods, which can be inefficient and hinder knowledge transfer due to redundant trial-and-error processes and difficulties in standardizing results. The complexity of biological systems, combined with large volumes of data, necessitates precise mathematical models like ordinary differential equations (ODEs) to describe interactions within these systems. However, the practical use of ODE-based models is limited by the need for curated data, making them less accessible for routine research. To overcome these challenges, we introduce LazyNet, a novel machine learning model that integrates logarithmic and exponential functions within a Residual Network (ResNet) to approximate ODEs. LazyNet reduces the complexity of mathematical operations, enabling faster model training with fewer data and lower computational costs. We evaluate LazyNet across several biological applications, including HIV dynamics, gene regulatory networks, and mass spectrometry analysis of small molecules. Our findings show that LazyNet effectively predicts complex biological phenomena, accelerating model development while reducing the need for extensive experimental data. This approach offers a promising advancement in computational biology, enhancing the efficiency and accuracy of biological research.

Source: Mathematical and Computational Applications

DOI: 10.3390/mca30030047

Author: Ziyue Yi

Institutions: Southeast University, Virginia Tech

Language: English

Topic: Model Reduction and Neural Networks

Subfield: Statistical and Nonlinear Physics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,689

Funder: Southeast University