Work

Discovery of the Aβ receptor that controls the voltage-gated sodium channel activity: unraveling mechanisms underlying neuronal hyperexcitability

Year: 2025

Type: article

Abstract: Alzheimer's disease (AD) is marked by memory loss and cognitive decline, with neuronal hyperactivity linked to amyloid beta peptides (Aβs) that enhance sodium channels. Using patch-clamp techniques, we determined that the receptor for Aβ corresponds to the type I taste receptor (T1R2/T1R3). This discovery reveals Aβ's physiological roles and offers a new molecular target for developing therapies to inhibit or modify Aβ binding, potentially regulating neurohyperactivity in AD.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00530.2024

Authors: Mitsuyoshi Luke Saito, Mitsuyoshi Luke Saito, Tsutomu Sasaki, Mariko Ruth Saito, Mariko Ruth Saito

Institutions: Ion Chat Research Corporation (Japan), The University of Osaka

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409924156

FWCI: 1.591

Cites: 52

Cited by: 3

Related to: 10