Year: 2025
Type: article
Abstract: Abnormal activation of pathways that detect nucleic acids has been linked to autoimmune diseases such as systemic lupus erythematosus (SLE).SLE is a systemic autoimmune condition marked by immune reactions against nucleic acids, overactivation of the type I interferon (IFN-I) pathway, and an increased risk of cardiovascular disease, including atherosclerosis.Liu et al demonstrated that the stimulator of IFN genes (STING), a sensor that detects nucleic acids inside cells, plays a key role in worsening autoimmunity, vascular damage, and atherosclerosis.
Source: Arthritis & Rheumatology
DOI: 10.1002/art.43192
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4409927149
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