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Role of c-ABL in DENV-2 Infection and Actin Remodeling in Vero Cells

Year: 2025
Type: article
Abstract: In this study, we address the role of c-ABL (cellular Abelson Tyr kinase) in the cytoskeletal rearrangements induced by DENV (Dengue virus) infection in mammalian cells. Using the specific inhibitor imatinib and targeted RNA interference, we show that c-ABL is necessary for viral entry and subsequent ENV (DENV envelope protein) accumulation in infected cells. In addition, c-ABL targeting attenuates F-actin reorganization induced by DENV infection. Together with the involvement of c-ABL in endothelial dysfunction induced by DENV and host secreted factors, our findings strongly suggest that c-ABL is a potential host-targeted antiviral that could control DENV infection and/or its evolution to more severe forms of the disease.
DOI: 10.3390/ijms26094206
Institutions: Universidad de Antioquia, University of Iowa, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer de Salamanca
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,499
Awards: G2440093645, G2652444522, G3029768985, G3278117794, G3710804940, G4056015203, G7143183700, G766600706, G7783465093
OpenAlex ID: W4409944577
FWCI: 0.826
Cites: 65
Cited by: 1
Related to: 10